Levocabastina [Spanish]
Brand names,
Levocabastina [Spanish]
Analogs
Levocabastina [Spanish]
Brand Names Mixture
Levocabastina [Spanish]
Chemical_Formula
C17H19F2N3O3
Levocabastina [Spanish]
RX_link
http://www.rxlist.com/cgi/generic2/lomefloxacin.htm
Levocabastina [Spanish]
fda sheet
Levocabastina [Spanish]
msds (material safety sheet)
Levocabastina [Spanish]
Synthesis Reference
No information avaliable
Levocabastina [Spanish]
Molecular Weight
351.348 g/mol
Levocabastina [Spanish]
Melting Point
239-240.5 oC
Levocabastina [Spanish]
H2O Solubility
27.2 mg/mL
Levocabastina [Spanish]
State
Solid
Levocabastina [Spanish]
LogP
1.781
Levocabastina [Spanish]
Dosage Forms
Tablet
Levocabastina [Spanish]
Indication
For the treatment of bacterial infections of the respiratory tract (chronic bronchitis) and urinary tract, and as a pre-operative prophylactic to prevent urinary tract infection caused by: S.pneumoniae, H.influenzae, S.aureus, P.aeruginosa, E. cloacae, P. mirabilis, C. civersus, S. asprphyticus, E.coli, and K.pneumoniae.
Levocabastina [Spanish]
Pharmacology
Lomefloxacin is a fluoroquinolone antibiotic used to treat chronic bronchitis, as well as complicated and uncomplicated urinary tract infections. It is also used as a prophylactic or preventative treatment to prevent urinary tract infections in patients undergoing transrectal or transurethral surgical procedures. Flouroquinolones such as lomefloxacin possess excellent activity against gram-negative aerobic bacteria such as E.coli and Neisseria gonorrhoea as well as gram-positive bacteria including S. pneumoniae and Staphylococcus aureus. They also posses effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter.
Levocabastina [Spanish]
Absorption
Rapid and nearly complete with approximately 95% to 98% of a single oral dose being absorbed.
Levocabastina [Spanish]
side effects and Toxicity
Adverse reactions include peripheral neuropathy, nervousness, agitation, anxiety, and phototoxic events (rash, itching, burning) due to sunlight exposure.
Levocabastina [Spanish]
Patient Information
Levocabastina [Spanish]
Organisms Affected
Enteric bacteria and other eubacteria